Background: There are a limited number of studies regarding the association between abdominal obesity and\nserum adiponectin complexes (high, medium, and low molecular weight adiponectins) among population-based\nelementary school children, especially in Japan, where blood collection is not usually performed during annual\nhealth examinations of school children. The aim of the present study was to investigate the relationship between\nabdominal obesity and serum adiponectin complexes among population-based elementary school children in\nJapan.\nMethods: Subjects were all the fourth-grade school children (9 or 10 years of age) in the town of Ina during\n2005ââ?¬â??2008 (N = 1675). The height, weight, percent body fat, and waist circumference (WC) of each subject were\nmeasured. Blood samples were drawn from subjects to measure adiponectin isoform values. Childhood abdominal\nobesity was defined as ââ?¬Å?a waist-to-height ratio greater than or equal to 0.5ââ?¬Â or ââ?¬Å?a WC greater than or equal to\n75 cmââ?¬Â. The Wilcoxon rank-sum test and the logistic regression model were used to analyze the association\nbetween abdominal obesity and each adiponectin isoform value.\nResults: Data from 1654 subjects (846 boys and 808 girls) were analyzed. Adiponectin complexes were lower in\nthe abdominal obesity group than in the non-abdominal obesity group regardless of sex. Abdominal obesity\nsignificantly increased the odds ratio (OR) for each adiponectin isoform level less than or equal to the median\nvalue in boys; the OR (95% confidence interval [CI]) was 2.50 (1.59-3.92) for high molecular weight adiponectin\n(HMW-adn), 2.47 (1.57-3.88) for medium molecular weight adiponectin (MMW-adn), and 1.75 (1.13-2.70) for low\nmolecular weight adiponectin (LMW-adn). In girls, the OR (95% CI) was 1.95 (1.18-3.21) for HMW-adn, 1.40 (0.86-2.28)\nfor MMW-adn, and 1.06 (0.65-1.70) for LMW-adn.\nConclusions: Abdominal obesity was associated with lower adiponectin complexes and the influence of abdominal\nobesity varied by adiponectin isoform. Furthermore, the impact of abdominal obesity was larger in boys than in\ngirls. The present study results suggest that prevention of abdominal obesity could contribute to the prevention of\nlower adiponectin levels, especially in boys.
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